| S.C.A.T.: Special Cybernetic Attack Team Game Details | Screens | Natsume | | |
| S.C.I.: Special Criminal Investigation Game Details | Screens | Taito | | |
| Sabre Wulf Game Details | Review | Screens | THQ | 9/10 | |
| Safecracker: The Ultimate Puzzle Adventure Game Details | Screens | JoWood | | |
| SaGa 2 Hiho Densetsu: Goddess of Destiny Game Details | Screens | Square Enix | | |
| SaGa 3: Jikuu no Hasha - Shadow or Light Game Details | Screens | Square Enix | | |
| Saint Game Details | Screens | UFO | | |
| Sakura Note Game Details | Screens | Marvelous | | |
| Sakura Wars: So Long, My Love Game Details | Review | Screens | NIS America | 9/10 | |
| Salamander Game Details | Screens | Konami | | |
| Salamander Game Details | Screens | Konami | | |
| Sam & Max: Beyond Time and Space Game Details | Screens | Atari | | |
| Sam and Max: Season One Game Details | Review | Screens | The Adventure Company | 7/10 | |
| Samantha Swift and the Hidden Roses of Athena Game Details | Review | Screens | MumboJumbo | 5/10 | |
| Samba de Amigo Game Details | Screens | SEGA | | |
| Samurai Ghost Game Details | Screens | Namco | | |
| Samurai Jack: The Amulet of Time Game Details | Screens | Zoo Digital | | |
| Samurai Jack: The Shadow of Aku Game Details | Screens | SEGA | | |
| Samurai Shodown Game Details | Screens | Takara | | |
| Samurai Shodown Game Details | Screens | D4 Enterprise | | |
| Samurai Shodown II Game Details | Screens | D4 Enterprise | | |
| Samurai Shodown III Game Details | Screens | D4 Enterprise | | |
| Samurai Shodown IV: Amakusa's Revenge Game Details | Screens | D4 Enterprise | | |
| Samurai Warriors 3 Game Details | Review | Screens | Nintendo | 5/10 | |
| Samurai Warriors Katana Game Details | Review | Screens | Koei | 6/10 | |
| San Francisco Rush 2049 Game Details | Screens | Midway | | |
| San Francisco Rush 2049 Game Details | Screens | Midway | | |
| Sands of Destruction Game Details | Screens | SEGA | | |
| Sangokushi Taisen DS Game Details | Screens | SEGA | | |
| Saturday Night Slam Masters Game Details | Screens | Capcom | | |
| Save The Turtles Game Details | Review | Screens | Sabarasa | 8/10 | |
| SBK: Snowboard Kids Game Details | Review | Preview | Screens | Rising Star | 4/10 | |
| Scarface: The World is Yours Game Details | Review | Screens | Vivendi | 8/10 | |
| Scene It? Bright Lights! Big Screen! Game Details | Screens | Warner Bros. | | |
| Scene It? Twilight Game Details | Screens | Konami | | |
| Scooby Doo! Mystery Mayhem Game Details | Screens | THQ | | |
| Scooby-Doo Mystery Game Details | Screens | Acclaim | | |
| Scooby-Doo! and the Spooky Swamp Game Details | Screens | Warner Bros. | | |
| Scooby-Doo! Classic Creep Capers Game Details | Screens | THQ | | |
| Scooby-Doo! Mystery Mayhem Game Details | Screens | THQ | | |
| Scooby-Doo! Night of 100 Frights Game Details | Screens | THQ | | |
| Scooby-Doo! Unmasked Game Details | Screens | THQ | | |
| Scooby-Doo! Who's Watching Who? Game Details | Review | Screens | THQ | 4/10 | |
| SCORE International Baja 1000: World Championship Off Road Racing Game Details | Screens | Activision | | |
| Scourge: Outbreak Game Details | Review | Screens | Bitbox Games | 4/10 | |
| Scrabble 2009 Edition Game Details | Screens | Ubisoft | | |
| Scribblenauts Game Details | Review | Screens | Warner Bros. | 7/10 | |
| Scribblenauts Collection Game Details | Screens | Warner Bros. | | |
| Scurge: Hive Game Details | Preview | Screens | SouthPeak | | |
| Scurge: Hive Game Details | Screens | SouthPeak | | |
| SD Gundam Dimension War Game Details | Screens | Bandai | | |
| SD Gundam World: Gachapon Senshi - Scramble Wars Game Details | Screens | Application Systems | | |
| SeaQuest DSV Game Details | Screens | Malibu | | |
| Second Sight Game Details | Review | Preview | Screens | Codemasters | 9/10 | |
| Secret Command Game Details | Screens | SEGA | | |
| Secret Files 2: Puritas Cordis Game Details | Review | Screens | Deep Silver | 8/10 | |
| Secret Files 2: Puritas Cordis Game Details | Screens | Koch | | |
| Secret Files Tunguska Game Details | Screens | Deep Silver | | |
| Secret Files: Tunguska Game Details | Screens | Deep Silver | | |
| Secret of Evermore Game Details | Screens | Square | | |
| Secret of Mana Game Details | Review | Screens | Nintendo | 9/10 | |
| Secrets of the Titanic: 1912-2012 Game Details | Review | Screens | Avanquest | 3/10 | |
| SEGA Bass Fishing Game Details | Review | Screens | SEGA | 6/10 | |
| SEGA Smash Pack Game Details | Screens | SEGA | | |
| SEGA Soccer Slam Game Details | Review | Screens | SEGA | 7/10 | |
| SEGA Superstars Tennis Game Details | Review | Screens | SEGA | 8/10 | |
| SEGA Superstars Tennis Game Details | Screens | SEGA | | |
| Seiken Densetsu 3 Game Details | Review | Screens | Squaresoft | 9/10 | |
| Seirei Senshi Spriggan Game Details | Screens | NAXAT | | |
| Sengoku 2 Game Details | Screens | D4 Enterprise | | |
| Sengoku 3 Game Details | Screens | SNK Playmore | | |
| Sengoku Basara 2 Heroes Game Details | Screens | Capcom | | |
| Sengoku Basara: Samurai Heroes Game Details | Review | Screens | Capcom | 7/10 | |
| Sengoku Mahjong Game Details | Screens | Hudson | | |
| Sennen Kazoku Game Details | Screens | Nintendo | | |
| Serious Sam: Next Encounter Game Details | Review | Preview | Screens | Climax | 8/10 | |
| Sesame Street: Elmo's Musical Monsterpiece Game Details | Screens | Warner Bros. | | |
| Sgt. Rock: On the Frontline Game Details | Screens | Bam | | |
| Shadow Dancer: The Secret of Shinobi Game Details | Screens | SEGA | | |
| Shadow Hearts Game Details | Screens | Midway | | |
| Shadow Land Game Details | Screens | Namcot | | |
| Shadow Man Game Details | Screens | Acclaim | | |
| Shadow of the Ninja Game Details | Screens | Natsume | | |
| Shadow the Hedgehog Game Details | Preview | Screens | SEGA | | |
| Shadowgate Game Details | Screens | Kemco | | |
| Shadowgate Classic Game Details | Screens | Nintendo | | |
| Shadowrun Game Details | Screens | Data East | | |
| Shaman King: Master of Spirits Game Details | Screens | Konami | | |
| Shanghai II: Dragon's Eye Game Details | Screens | Activision | | |
| Shanghai II: Dragon's Eye Game Details | Screens | Activision | | |
| Shantae Game Details | Review | Screens | Capcom | 7/10 | |
| Shantae: Risky's Revenge Game Details | Review | Screens | WayForward | 8/10 | |
| Shaq-Fu Game Details | Screens | EA | | |
| Shaun White Skateboarding Game Details | Preview | Screens | Ubisoft | | |
| Shaun White Snowboarding: World Stage Game Details | Screens | Ubisoft | | |
| Shenmue II Game Details | Screens | SEGA | | |
| Sherlock Holmes and the Mystery of Osborne House Game Details | Review | Screens | Focus Home | 6/10 | |
| Sherlock Holmes: Crimes & Punishments Game Details | Review | Screens | Focus Home | 7/10 | |
| Sherlock Holmes: Mystery of the Mummy Game Details | Screens | Frogwares | | |
| Sherlock Holmes: The Silver Earring Game Details | Screens | Dreamcatcher | | |