| Sam & Max: Beyond Time and Space Game Details | Screens | Atari | | |
| Sam and Max: Season One Game Details | Review | Screens | The Adventure Company | 7/10 | |
| Scarface: The World is Yours Game Details | Review | Screens | Vivendi | 8/10 | |
| Scooby-Doo! and the Spooky Swamp Game Details | Screens | Warner Bros. | | |
| Secret Files 2: Puritas Cordis Game Details | Screens | Koch | | |
| Secret Files Tunguska Game Details | Screens | Deep Silver | | |
| Sherlock Holmes: Mystery of the Mummy Game Details | Screens | Frogwares | | |
| Sherlock Holmes: The Silver Earring Game Details | Screens | Dreamcatcher | | |
| Shiren the Wanderer Game Details | Screens | Atlus | | |
| SoulCalibur Legends Game Details | Screens | Ubisoft | | |
| Spider-Man: Edge of Time Game Details | Screens | Activision | | |
| Spider-Man: Shattered Dimensions Game Details | Preview | Screens | Activision | | |
| Spongebob Squarepants: Creature From The Krusty Krab Game Details | Screens | THQ | | |
| Spore Hero Game Details | Review | Preview | Screens | EA | 5/10 | |
| SPRay Game Details | Screens | Tecmo | | |
| Star Wars The Clone Wars: Republic Heroes Game Details | Screens | LucasArts | | |
| Star Wars: The Clone Wars - Lightsaber Duels Game Details | Preview | Screens | LucasArts | | |
| Strong Bad Game Details | Review | Screens | Telltale | 8/10 | |
| Strong Bad Episode 2: Strong Badia the Free Game Details | Review | Screens | Telltale | 9/10 | |
| Strong Bad Episode 3: Baddest of the Bands Game Details | Review | Screens | Telltale | 7/10 | |
| Strong Bad Episode 4: Dangeresque 3 Game Details | Review | Screens | Telltale | 8/10 | |
| Strong Bad Episode 5: 8-Bit is Enough Game Details | Review | Screens | Telltale | 9/10 | |