Voice Actor Josh Keaton has let slip that he'll be reprising his role as Destory Man in the sequel to No More Heroes.
No More Heroes: Desperate Struggle is the follow up to Suda51/Grasshopper's unique Wii action game, penned for a release sometime in 2010. As well as protagonist Travis Touchdown, it looks as if characters from the original will also return.
I finished doing a Destroy Man part on a game called No More Heroes, which was popular. He's kind of an unapologetic jerk of a character, and he makes a return in what I'm assuming is a second installment of that game, so I just finished that. - Josh Keaton
Thanks to GoNintendo.