| Sakura Wars: So Long, My Love | NIS America | 9/10 | |
| Sam and Max: Season One | The Adventure Company | 7/10 | |
| Samurai Warriors 3 | Nintendo | 5/10 | |
| Samurai Warriors Katana | Koei | 6/10 | |
| Scarface: The World is Yours | Vivendi | 8/10 | |
| SEGA Bass Fishing | SEGA | 6/10 | |
| SEGA Superstars Tennis | SEGA | 8/10 | |
| Sengoku Basara: Samurai Heroes | Capcom | 7/10 | |
| Sid Meier's Pirates! | 2K | 5/10 | |
| Silent Hill: Shattered Memories | Konami | 9/10 | |
| SimAnimals: Africa | EA | 4/10 | |
| Sin and Punishment 2: Successor of the Skies | Nintendo | 10/10 | |
| Smarty Pants | EA | 7/10 | |
| SNK Arcade Classics Vol. 1 | Ignition | 7/10 | |
| Soccer Bashi | Icon | 4/10 | |
| Sonic & SEGA All-Stars Racing | SEGA | 7/10 | |
| Sonic and the Black Knight | SEGA | 6/10 | |
| Sonic and the Secret Rings | SEGA | 8/10 | |
| Sonic Colours | SEGA | 8/10 | |
| Sonic Riders: Zero Gravity | SEGA | 6/10 | |
| Sonic the Hedgehog 4 - Episode I | SEGA | 7/10 | |
| Sonic Unleashed | SEGA | 6/10 | |
| Speed Zone (Wheelspin) | Detn8 | 5/10 | |
| Spider-Man 3 | Activision | 4/10 | |
| Spider-man: Friend or Foe | Activision | 6/10 | |
| Spore Hero | EA | 5/10 | |
| SSX Blur | EA Sports | 8/10 | |
| Star Soldier R | Hudson | 8/10 | |
| Stop Stress: A Day of Fury | Abylight | 4/10 | |
| Strong Bad Episode 1: Homestar Ruiner | Telltale | 8/10 | |
| Strong Bad Episode 2: Strong Badia the Free | Telltale | 9/10 | |
| Strong Bad Episode 3: Baddest of the Bands | Telltale | 7/10 | |
| Strong Bad Episode 4: Dangeresque 3 | Telltale | 8/10 | |
| Strong Bad Episode 5: 8-Bit is Enough | Telltale | 9/10 | |
| Summer Challenge: Athletics Tournament | pQube | 5/10 | |
| Super Mario Galaxy | Nintendo | 10/10 | |
| Super Mario Galaxy 2 | Nintendo | 10/10 | |
| Super Monkey Ball: Banana Blitz | SEGA | 5/10 | |
| Super Monkey Ball: Step & Roll | SEGA | 6/10 | |
| Super Paper Mario | Nintendo | 7/10 | |
| Super Smash Bros. Brawl | Nintendo | 9/10 | |
| Super Smash Bros. Brawl | Nintendo | 9/10 | |
| Super Swing Golf | Rising Star | 7/10 | |
| Swords & Soldiers | Ronimo | 8/10 | |