Yes, definitely, its really good fun. It's more of the same with the same characters, but the story is good and there are plenty of new additions to explore, and Rome is HUGE. I'm on Sequence 5 at the moment, taking it slow as I have work etc, but it sucks you in as much as any other Assassins Creed. The multiplayer is also good fun, just read THIS
Awesome. I got so sucked into AC2, it was like reading a good book and didn't want to put it down. I just hope they didn't pull the whole corrupted memory shit to release as DLC.