It would be a day one purchase for me as well. I've put around 500 hours into MH3 because it was just so much fun, both offline and online. It didn't bother me at all that it was on a home console because I'd play it the whole day anyway. I agree with Echoes though, it really is more suited to handhelds for quickly doing one or two quests and then putting it away again. Even then, I'd probably find myself playing it the whole day with my AC adapter plugged in all the time.
I'm used to dual analog for MH as MH3 with the CC Pro was the only game of the series I've played but I'm sure that Capcom will find a good way to make that work for the 3DS. The PSP only had one analog stick as well and that didn't stop millions of people buying and enjoying its MH games.
The funny (or sad) thing here is, I already put like 500 hours into MH3 and it actually had much less content compared to Monster Hunter Freedom Unite or Portable 3rd (still a ton though). Now if Capcom brings out a 3DS game with as much content as those two PSP iterations...I don't think my social life could survive that.
( Edited 15.07.2011 05:57 by SirLink )